Safety of Newer Parenteral Antibiotics

Linical Assessment of the Newer Antibiotics

On Reactions with the Newer Antibiotics

most are not serious. Reactions are more likely to happen when the daily dosage is high or when administration is prolonged. Most of the untoward effects occur in the gastro-intestinal tract and this system seems more susceptible in women than in men. Other systems of the body are affected far less frequently. With oral therapy about forty per cent of patients develop some symptoms of signs in ...

Particulate Contamination in Single-Dose Parenteral Antibiotics in Iran

      In order to ensure the safety of parenterals, international pharmacopoeias and national standards have set up stringent guidelines and standards. Particulate con- tamination is a potential health risk caused by intravenous injection of particles large enough to potentially clog the small arteries. Particles could be produced through manufacturing and packaging or even dispensing of the ph...

Safety of Parenteral Hydroxypropyl /?-Cyclodextrin

0 Post-treatment data were collected on a patient who received intravenous hydroxypropyl P-cyclodextrin in a dose of 1.5 g/kg in 1985. Although no untoward effects were observed in this patient, rarely occurring agitation and pulmonary edema have been noted after injections into rabbits and dogs, respectively. These complications are analyzed here on the basis of symptoms and on the effects of ...

Mechanisms of action of newer antibiotics for Gram-positive pathogens.

Certain Gram-positive bacteria, including meticillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and quinolone-resistant Streptococcus pneumoniae have achieved the status of "superbugs", in that there are few or no antibiotics available for therapy against these pathogens. Only a few classes of novel antibiotics have been introduced in the past 40 years, and all since 199...